How to request a ReceptivaDx™ test: your step-by-step guide

From pelvic inflammation and common symptoms to the more surprising ones – acid reflux, anybody? – we’ve covered a huge range of topics related to endometriosis, both silent and symptomatic. 

Endometriosis is a common cause of infertility, yet getting a diagnosis can take years – and in some cases, even decades. For team TRB, anything we can do to take the reins and advocate for support and diagnosis is compelling, and for suspected endometriosis, the go-to is ReceptivaDx. This test looks for BCL6, a marker of inflammation in the uterine lining associated with endometriosis.

ReceptivaDx testing involves an endometrial biopsy (read our guide to self care after a biopsy for lots of detail), and analysis in a specialist laboratory. Your results can provide additional information to help guide conversations about endometriosis, fertility and potential treatment options.

But how do you actually ask for the test? Do you need a referral, where can you have the biopsy, and how much does it cost?

If you’re requesting ReceptivaDx, the reason for asking will depend on which specialist you’re seeing. If you’re already under the care of a reproductive endocrinologist because of unexplained infertility, implantation failure may be your reason to discuss testing.

On the other hand, if you’re seeing an OB/GYN or another doctor, symptoms such as pelvic pain, recurrent pregnancy loss or difficulty getting pregnant may prompt a conversation about testing for BCL6.

Today, we’re breaking down the process with input from the team behind ReceptivaDx, so you know what to ask, what to expect and how to feel more confident heading into your appointment.

What is the ReceptivaDx test?

ReceptivaDx is a test that analyzes a sample of the endometrium, the lining of the uterus, to look for BCL6, a protein marker associated with inflammation and endometriosis.

It can be tricky to identify endo – especially if symptoms are ‘silent’. In some cases, the condition may be completely hidden until unexplained infertility becomes an issue, or more specifically embryo implantation failure, and/or recurrent miscarriage. 

Bear in mind, the BCL6 test isn’t a definitive diagnosis tool. Laparoscopy is still the established method for confirming endometriosis, but BCL6 testing can help identify inflammation associated with the condition before opting for surgical investigation. 

BCL6 is a marker of inflammation associated with endometriosis, and is found in more than 50% of women with unexplained infertility and 65% of women with two or more IVF failures. 

A full pathology report

Your ReceptivaDx results come with a full pathology report, providing your BCL6 status alongside endometrial dating to help establish whether the biopsy was taken during the correct phase of your menstrual cycle.

The report also evaluates abnormal cellular changes (dysplasia), and CD138 can be requested as an add-on marker to assess for chronic endometritis – an inflammation of the uterine lining often associated with bacterial infection.

Concerned about fertility, or plans for IVF? Pin our guide to endometriosis, infertility and IVF.

1. How do I request a ReceptivaDx test?

First up, contact your OBGYN, fertility specialist or reproductive endocrinologist and ask whether the ReceptivaDx test might be right for you. Explain your concerns and symptoms, as well as any investigations you’ve already had, previous pregnancy losses, unsuccessful IVF cycles or ongoing pain.

Here’s an example of how you might ask the question, in conversation with your doctor. Plus, what to bring to your appointment. 

Bring along:

• A symptom journal (dates, frequency and pain scores of 1-10 can really help here. Try a symptom tracker app, like Bearable, to keep things clear and easy to find)
• Notes on how symptoms affect your life (for example work, fatigue levels, relationships, parenting responsibilities, sex)
• A clear request – the ReceptivaDx team have helped out here with some wording to get you started.

Speak with clarity:

“I’ve now had X miscarriages / X failed IVF cycles and my infertility issues are categorized as ‘unexplained’. I’ve been tracking other symptoms too, and they’re consistent with what I’ve read about endometriosis. 

I understand that diagnosis can be tricky and requires laparoscopy for a definitive confirmation, but I’ve read about this test – ReceptivaDx – which will allow me to get some answers now before I get referred to a surgeon.  

Can we discuss ordering the kit? It’s a timed biopsy and requires me to have the sample taken within a specific timeframe. I’d like to discuss what steps we can take to make this happen and if positive, then move to a referral to a specialist.”

The test comes with a doctor info sheet and QR code to make the process easy to follow. Most OBs are comfortable doing the biopsy, so just ask.

Unsure where to start? Skip to ReceptivaDx to find information about testing centers and providers. The team can also help you explore your options if you can’t find a center local to you.

2. Do I need a doctor to order the test?

Yes, a licensed medical professional must order the test and arrange for the endometrial tissue sample to be collected.

A fertility specialist, OBGYN or expert healthcare provider who performs endometrial biopsies may be able to take the sample.

You don’t need to be an IVF patient to ask about testing, but your clinician will need to decide whether it’s the right course of action for you.

Not on an IVF journey? ReceptivaDx give specific support if this is the case – for example if you suspect your fertility or wellbeing concerns may be due to endometriosis or endometritis.

3. Where can I have the test done?

A biopsy can usually be performed during your appointment with a provider who offers endometrial sampling. They’ll also need access to the appropriate ReceptivaDx collection kit. 

Check with your clinic before booking to confirm that it can perform the test and can arrange the necessary timing. Direct them to the Get started area of receptivadx.com for provider-specific information on how to order. 

Hitting a dead end? If your usual provider can’t help with testing, contact ReceptivaDx for support with finding a centre.

4. How much does ReceptivaDx testing cost?

The BCL6 test and pathology report cost $690 USD. An optional CD138 test costs an additional $145 USD. Confirm current pricing and any applicable charges directly with the provider.

 Is it covered by insurance?

ReceptivaDx don’t bill insurance plans directly. However, they can provide detailed receipts which you can then submit to your insurer for potential reimbursement. Your doctor may also provide the relevant diagnostic coding. 

Cover depends on your insurer, your policy and your circumstances. Contact your insurance provider before testing to check what’s possible and any paperwork or input from your OBGYN or healthcare provider that may be required.

Based in the UK, or internationally? Contact ReceptivaDx directly for information about ordering, sample shipping and payment arrangements.

5. What happens after the biopsy, and when will I receive my results?

Once your sample has been collected, it is sent to the laboratory for analysis. Results are generally made available to your doctor or healthcare provider within 7-10 days.

From there, your doctor will explain the findings and discuss any further investigations or treatment options.

If you test positive, this result indicates a high level of BCL6 and uterine lining inflammation most often associated with endometriosis.

A negative result suggests a high likelihood that no inflammation is present, helping you rule out endometriosis as a possible symptom cause.

Your next steps will depend on your results, symptoms, medical history and fertility goals. Ask your doctor what the findings mean for you and whether referral to an endometriosis specialist or further investigation would be helpful.

You can also arrange a free telephone consultation through ReceptivaDx if you have questions about the test itself.