Causes & Treatment

What does unexplained infertility mean, really?

Emma Harpham, in partnership with ReceptivaDx™  |  14 Dec 2023


Wondering what does unexplained infertility mean for you (or your partner)?

Getting to the bottom of unexplained infertility and what it means for your treatment options and next steps is probably one of the most difficult things to go through, when you’re on a family-building journey (not that any of it is easy, though).

Watch as we demystify the term, and shed light on what unexplained infertility really means. Curious about the potential game-changer – the BLC6 test – and how it could enhance your chances of success? We’ve got you covered. Plus, we’ll debunk the myth surrounding silent endometriosis and its impact on fertility.

We’re joined by Dr. Brian Levine, Founder and Practice Director of CCRM Fertility of New York to get his expert insight.

If you have been diagnosed with unexplained infertility and are keen to rule out endometriosis, we turn to ReceptivaDx™ every time. From questions to ask your doctor to the tests to ask for, they work to raise awareness around the primary causes and breakthrough treatment for unexplained infertility, repeat IVF failure and pregnancy loss.

TRB readers can claim $75 off a ReceptivaDx test with code TRB23

What does unexplained infertility mean? Is it uncommon?

So, what does unexplained infertility mean? Usually, it’s when standard fertility testing methods can’t find a cause to ‘explain’ your infertility, Dr Levine explains.

“Unexplained infertility is one of the most frustrating diagnoses that a patient can receive.

When someone is diagnosed with unexplained infertility, we need to stop and take a look to figure out what’s actually going on – instead of continuing to move forward through treatments without a clear diagnosis.”

Can a BCL6 test help with my unexplained infertility and improve my chances of success?

Unexplained infertility can mean that other fertility testing methods need to be explored. Dr Levine explains;

“One of the tools in my clinical practice is the ReceptivaDx test, where we can better understand the level of a certain protein called BCL6.

BCL6 can be elevated for someone with:

– hydrosalpinges (fluid in the fallopian tube)
– swollen fallopian tubes
– silent endometriosis
– raging endometriosis
– an inflammation or infection within the pelvis

We know that we can treat this BCL6 with certain treatment protocols. So I deploy the ReceptivaDx test for patients where I’m either concerned about some inflammatory process occurring or for those who may not have been successful with a transfer.”

Does silent endometriosis mean I can’t get pregnant?

Dr Levine shares his expertise on unexplained infertility, and how it’s still possible to have a successful transfer after a silent endometriosis diagnosis.

“This is one of the most common questions I get from patients when they find out they have silent endometriosis.

And what I tell them is, of course, pregnancy is possible.

Part of their treatment protocol involves a swift identification of their problem, creating a linear and logical treatment plan that actually addresses their problem, and most importantly, using evidence-based data.”

Unexplained infertility – more of a placeholder, than a hard stop

Understanding unexplained infertility is a crucial step towards your fertility journey. The BLC6 test offers hope with the potential to improve your chances of success. And, importantly, unexplained infertility and silent endometriosis don’t close the door to pregnancy – it’s about finding the right strategies.

If you’re keen to understand your unexplained infertility, connect with ReceptivaDx™ to book your test and move forward with your treatment.

Remember, TRB readers can claim $75 off a ReceptivaDx test with code TRB23

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